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Purpose@#To determine the clinical significance of choroidal thickness and evaluate changes in choroidal thickness over time in eyes affected by ocular ischemic syndrome (OIS). @*Methods@#Medical records of 16 patients diagnosed with OIS between November 2017 and August 2019 were retrospectively reviewed. In every nine areas of the Early Treatment Diabetic Retinopathy Study grid, we compared the differences in choroidal thickness between the eyes with OIS and unaffected eyes, and its change in the OIS eyes during the follow-up period using swept-source optical coherence tomography. We analyzed the best-corrected visual acuity, intraocular pressure, fluorescein angiography (FAG) parameters, systemic diseases, and the duration of symptoms. Correlation between FAG parameters and the choroidal thickness value ratio in the OIS eyes and the unaffected eyes, and changes in the choroidal thickness in the OIS eyes during follow-up were investigated. @*Results@#Median age of the subjects was 67.5 years. In the OIS eyes, all FAG parameters were delayed at the initial examination. Best-corrected visual acuity and intraocular pressure were significantly different between the OIS and unaffected eyes. While the choroidal thickness in every nine areas of Early Treatment Diabetic Retinopathy Study in the OIS eyes was lesser than the unaffected eyes, the choroidal thickness of inner temporal, outer nasal, and outer temporal area showed statistically significant difference. During follow-up, changes in choroidal thickness of OIS eyes as well as correlation between the FAG parameters and the choroidal thickness value ratio between the OIS eyes and the unaffected eyes were not found to be statistically significant. @*Conclusions@#The choroidal thickness of the eyes with OIS was significantly less compared with the unaffected eyes. We inferred that choroidal thinning takes place in the early phase of the disease as the changes in choroidal thickness during the follow-up period were not significant.
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Pregnancy-related ocular diseases develop mostly in the third trimester of pregnancy. Here, we describe a case of a pregnant woman with a choroidal mass that caused a serous retinal detachment during the first trimester of pregnancy. The patient’s condition resolved spontaneously after an abortion.
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Background@#The coronavirus disease 2019 (COVID-19) has reportedly affected almost 23 million people, with more than 800 thousand deaths globally. There have been a few reports on the ocular manifestations of COVID-19 patients in China but no reports in Korea. The present study aimed to examine ocular manifestations of COVID-19 patients in Korea. @*Methods@#COVID-19 patients admitted from March 2020 to April 2020 at Keimyung University Dongsan Hospital and Keimyung University Daegu Dongsan Hospital were reviewed retrospectively for ocular manifestations. During the period of hospitalization, ocular symptoms as well as blood test results were noted and analyzed. Patients were then divided into the first-episode and relapsed group and ocular symptoms were analyzed in the groups. @*Results@#A total of 103 patients were included in this study. Among them, 71patients were in the first-episode group and 32 patients in the relapsed group. No significant differences were determined in terms of positivity of ocular symptoms between the first-episode group (12 patients, 16.9%) and the relapsed group (10 patients, 31.3%, p > 0.05). Symptoms of positive upper respiratory infection and lower creatine phosphokinase were determined to be related to positive ocular symptoms. Conjunctival congestion was noted in seven patients. In the subgroup analysis, the conjunctival congestion-positive patients exhibited higher positivity of upper respiratory infection symptoms (100%) as compared with those in the negative group (40%, p = 0.017). @*Conclusion@#Positive upper respiratory infection symptoms and lower creatine phosphokinase were determined to be related to ocular symptoms in COVID-19 patients.Among these patients, positive upper respiratory infection symptoms were associated with conjunctival congestion.
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Purpose@#We describe the use of optical coherence tomography angiography (OCTA) to investigate the relationship between thyroid-stimulating hormone receptor autoantibody (TSHR Ab) levels and retinal vessel and choroid changes in patients with thyroid eye disease (TED). @*Methods@#We enrolled 23 TED patients with abnormal TSHR Ab levels (>1.5 IU/L; all right eyes). Sex, visual acuity, intraocular pressure and TSHR Ab level were recorded at baseline and after 1 month. We used OCTA to determine the size of the superficial and deep foveal avascular zones (sFAZ and dFAZ, respectively), as well as the 1-mm foveal and 3-mm parafoveal superficial capillary plexus density (sCPD) and choroidal thickness (CT), at baseline and after 1 month later. @*Results@#The mean age of the 23 patients was 43.30 ± 16.16 years and 18 were female (78%). The mean baseline TSHR Ab level was 11.47 ± 11.22 IU/L. The TSHR Ab level showed non-significant correlations with sFAZ and dFAZ size, and with the 1-mm foveal sCPD; the correlation coefficients were 0.173, 0.073, and 0.266, respectively (p = 0.465, p = 0.759, and p = 0.224, respectively). The 3-mm parafoveal sCPD and CT showed non-significant correlations with the TSHR Ab level; the correlation coefficients were -0.185 and -0.16 (p = 0.421, p = 0.487). @*Conclusions@#In TED patients, changes in TSHR Ab level over 1 month do not affect retinal blood flow or CT, but show a non-significant positive association with the 1-mm foveal sCPD.
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Purpose@#We describe the use of optical coherence tomography angiography (OCTA) to investigate the relationship between thyroid-stimulating hormone receptor autoantibody (TSHR Ab) levels and retinal vessel and choroid changes in patients with thyroid eye disease (TED). @*Methods@#We enrolled 23 TED patients with abnormal TSHR Ab levels (>1.5 IU/L; all right eyes). Sex, visual acuity, intraocular pressure and TSHR Ab level were recorded at baseline and after 1 month. We used OCTA to determine the size of the superficial and deep foveal avascular zones (sFAZ and dFAZ, respectively), as well as the 1-mm foveal and 3-mm parafoveal superficial capillary plexus density (sCPD) and choroidal thickness (CT), at baseline and after 1 month later. @*Results@#The mean age of the 23 patients was 43.30 ± 16.16 years and 18 were female (78%). The mean baseline TSHR Ab level was 11.47 ± 11.22 IU/L. The TSHR Ab level showed non-significant correlations with sFAZ and dFAZ size, and with the 1-mm foveal sCPD; the correlation coefficients were 0.173, 0.073, and 0.266, respectively (p = 0.465, p = 0.759, and p = 0.224, respectively). The 3-mm parafoveal sCPD and CT showed non-significant correlations with the TSHR Ab level; the correlation coefficients were -0.185 and -0.16 (p = 0.421, p = 0.487). @*Conclusions@#In TED patients, changes in TSHR Ab level over 1 month do not affect retinal blood flow or CT, but show a non-significant positive association with the 1-mm foveal sCPD.
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PURPOSE: To determine the correlations of intraocular pressure (IOP) with risk factors in rhegmatogenous retinal detachment (RRD) patients. METHODS: A total of 113 eyes in 113 consecutive patients with RRD were enrolled in this study. IOP was measured using applanation tonometry at the initial visit. Based on the difference in IOP between the affected and unaffected eyes, the subjects were divided into two groups: group 1 (IOP difference ≤ 2 mmHg) and group 2 (IOP difference > 2 mmHg). Correlations between the IOP and RRD morphology, visual acuity (VA), best-corrected VA (BCVA), retinal break size and location, range of retinal detachment, macular involvement, and proliferative vitreoretinopathy were analyzed. RESULTS: The IOP at the initial visit was 12.88 ± 3.2 mmHg in the affected eyes and 14.27 ± 2.5 mmHg in the unaffected eyes. The IOP difference between the affected and unaffected eyes was −1.40 ± 2.82 mmHg. The BCVA and range of retinal detachment showed statistically significant differences between groups 1 and 2. CONCLUSIONS: In patients with RRD, the IOP difference compared to the unaffected eye was correlated with the extent of area of retinal detachment and decreased BCVA.
Subject(s)
Humans , Intraocular Pressure , Manometry , Retinal Detachment , Retinal Perforations , Retinaldehyde , Risk Factors , Visual Acuity , Vitreoretinopathy, ProliferativeABSTRACT
PURPOSE: To evaluate the efficacy and safety of pars plana posterior capsulectomy (PPPC) during phacovitrectomy. METHODS: In this retrospective study, 76 patients (76 eyes) who underwent phacovitrectomy were enrolled. The patients were divided into two groups according to whether PPPC was performed during phacovitrectomy. In group A, PPPC using a vitreous cutter was combined with phacovitrectomy; in group B, only phacovitrectomy was performed. The best-corrected visual acuity (BCVA), predicted and actual refractive errors, adverse events, and posterior capsular opacity (PCO) were analyzed and compared between the two groups. RESULTS: Age, sex, and pre- and postoperative BCVA were not significantly different between group A (n = 37) and group B (n = 39). No intraoperative complications were identified in either group. In group A, the actual refraction (postoperative 2 months) was −0.44 ± 0.88 diopters (D) and a mild hyperopic shift was found compared to the preoperative predicted refraction (−0.56 ± 0.40 D). In group B, the actual refraction was −0.70 ± 0.72 D and a mild myopic shift was found compared to the preoperative predicted refraction (−0.60 ± 0.81 D). The difference in refraction shifts between the two groups was not significant but very close to it (p = 0.050). In group A, yttrium-aluminum-garnet (YAG) laser posterior capsulotomy was not required. However, PCO was observed in 10 eyes in group B, 6 of which subsequently underwent YAG laser posterior capsulotomy at the last follow-up. Lens instability such as dislocation or subluxations was not observed during the follow-up period. CONCLUSIONS: PPPC combined with phacovitrectomy may lead to hyperopic refractive changes. However, this was a safe and effective approach to prevent PCO and additional YAG laser posterior capsulotomy.
Subject(s)
Humans , Capsule Opacification , Joint Dislocations , Follow-Up Studies , Intraoperative Complications , Lasers, Solid-State , Phacoemulsification , Posterior Capsulotomy , Refractive Errors , Retrospective Studies , Visual Acuity , VitrectomyABSTRACT
Cephalopods have the most advanced nervous systems and intelligent behavior among all invertebrates. Their brains provide comparative insights for understanding the molecular and functional origins of the human brain. Although brain maps that contain information on the organization of each subregion are necessary for a study on the brain, no whole brain atlas for adult cephalopods has been constructed to date. Here, we obtained sagittal and coronal sections covering the entire brain of adult Octopus minor (Sasaki), which belongs to the genus with the most species in the class Cephalopoda and is commercially available in East Asia throughout the year. Sections were stained using Hematoxylin and Eosin (H&E) to visualize the cellular nuclei and subregions. H&E images of the serial sections were obtained at 30~70-µm intervals for the sagittal plain and at 40~80-µm intervals for the coronal plain. Setting the midline point of the posterior end as the fiducial point, we also established the distance coordinates of each image. We found that the brain had the typical brain structure of the Octopodiformes. A number of subregions were discriminated by a Hematoxylin-positive layer, the thickness and neuronal distribution pattern of which varied markedly depending upon the region. We identified more than 70 sub-regions based on delineations of representative H&E images. This is the first brain atlas, not only for an Octopodiformes species but also among adult cephalopods, and we anticipate that this atlas will provide a valuable resource for comparative neuroscience research.
Subject(s)
Adult , Humans , Arm , Brain , Cephalopoda , Eosine Yellowish-(YS) , Asia, Eastern , Hematoxylin , Histology, Comparative , Invertebrates , Nervous System , Neurons , Neurosciences , OctopodiformesABSTRACT
PURPOSE: To evaluate the clinical differences between patients with central serous chorioretinopathy (CSC) developed after steroid use and CSC patients without a history of steroid use for short-term periods. METHODS: We retrospectively analyzed the medical records of 47 patients (55 eyes) diagnosed with CSC from January 2011 to August 2017 by categorizing Group 1 (32 patients, 36 eyes) without a history of steroid use and Group 2 (15 patients, 19 eyes) with a history of steroid use within 6 months. We evaluated the differences in best-corrected visual acuity (BCVA), subretinal fluid (SRF) height, subfoveal choroidal thickness (SFCT), and Haller's layer thickness in the two groups. We also analyzed the changes in the BCVA, SRF height, SFCT, and Haller’s layer thickness in each group for 1 month and compared them depending on the treatment. RESULTS: There were no significant differences between the two groups with regard to age, sex, BCVA, bilaterality, number of leakage points, and Haller's layer thickness. Group 2 showed significantly increased SRF height and SFCT than Group 1 (p = 0.002, p = 0.005, respectively). In Group 1, the level of SRF and SFCT were significantly more decreased after 1 month (p = 0.001, 0.015, respectively) in patients with treatment than in those without treatment. In Group 2, the height of the SRF and SFCT were significantly more decreased after 1 month (p = 0.005, 0.002, respectively) in untreated patients compared to treated patients. CONCLUSIONS: CSC patients with a prior history of steroid use have higher serous detachment and a thicker SFCT than those without prior history of steroid use. Therefore, termination of steroid treatment may reduce the SFCT and SRF in steroid-treated CSC patients.
Subject(s)
Humans , Central Serous Chorioretinopathy , Choroid , Medical Records , Retrospective Studies , Subretinal Fluid , Visual AcuityABSTRACT
Fabry disease (FD) is an X-linked, recessively inherited, rare, progressive, disorder of glycosphingolipid metabolism affecting multiple organs resulting in organ dysfunction. It is rare to find only one FD affected subject with a de novo mutation. Here we report a case of a 41-year-old Asian male diagnosed with de novo FD. Comprehensive ophthalmological evaluation was performed using slit lamp, color fundus photography, optical coherence tomography, fluorescein angiography, and indocyanine green angiography. On slit lamp examination, cornea verticillata and slightly tortuous, and aneurysmal dilatation of inferior bulbar conjunctival vessels were observed. Other imaging modalities showed unremarkable findings. Cornea verticillata and inferior bulbar conjunctival vascular abnormalities may be detected earlier than other ocular abnormalities in de novo FDs like hereditary FDs.
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Fabry disease (FD) is an X-linked, recessively inherited, rare, progressive, disorder of glycosphingolipid metabolism affecting multiple organs resulting in organ dysfunction. It is rare to find only one FD affected subject with a de novo mutation. Here we report a case of a 41-year-old Asian male diagnosed with de novo FD. Comprehensive ophthalmological evaluation was performed using slit lamp, color fundus photography, optical coherence tomography, fluorescein angiography, and indocyanine green angiography. On slit lamp examination, cornea verticillata and slightly tortuous, and aneurysmal dilatation of inferior bulbar conjunctival vessels were observed. Other imaging modalities showed unremarkable findings. Cornea verticillata and inferior bulbar conjunctival vascular abnormalities may be detected earlier than other ocular abnormalities in de novo FDs like hereditary FDs.
Subject(s)
Adult , Humans , Male , Aneurysm , Angiography , Asian People , Cornea , Dilatation , Fabry Disease , Fluorescein Angiography , Indocyanine Green , Metabolism , Photography , Slit Lamp , Tomography, Optical CoherenceABSTRACT
PURPOSE: To evaluate ocular findings of patients with acute cerebral infarction by analyzing fluorescein angiography (FAG) and optical coherence tomography (OCT). METHODS: We retrospectively reviewed the medical records of patients with acute cerebral infarction. FAG was used to analyze arm to retina time and arteriovenous (AV) transit time. The peripapillary retinal nerve fiber layer (pRNFL) was analyzed using OCT, and the data were compared with those of patients diagnosed with idiopathic epiretinal membrane (control group). RESULTS: Seventy-three patients were included in the patient group, and 56 participants were in the control group. In 27% of the subjects in the patient group, retinal abnormality was incidentally identified. Atrial fibrillation (p < 0.050) was the only systemic disease with a significantly higher incidence in the patient group. AV transit time (p < 0.050) showed a significant delay in the patient group, but there was no significant difference in the arm to retina time. pRNFL thickness did not significantly differ between the ipsilateral and contralateral locations of brain lesion. In addition, there was no significant difference in the subgroup analysis according to cerebral ischemic territory and no correlation between the severity of symptoms and the findings of ophthalmologic examination. CONCLUSIONS: Patients with acute cerebral infarction show delayed AV transit time in FAG, and about 27% of them have unrecognized retinal abnormalities.
Subject(s)
Humans , Arm , Atrial Fibrillation , Brain , Cerebral Infarction , Epiretinal Membrane , Fluorescein Angiography , Fluorescein , Incidence , Medical Records , Nerve Fibers , Retina , Retinaldehyde , Retrospective Studies , Tomography, Optical CoherenceABSTRACT
Dengue fever is an acute febrile disease that is caused by a mosquito-borne flavivirus. It has become a major infectious disease threat in tropical and subtropical areas. In Korea, travel-associated dengue fever is increasing. Thirty-five Koreans went to Sri Lanka to do volunteer activities. Eight of the volunteers developed fever, myalgia, and rash; they were diagnosed with dengue fever. Two patients had macular hemorrhages and edema with no ophthalmic symptoms. The maculopathy caused by the dengue fever improved without specific treatment.
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Humans , Communicable Diseases , Dengue , Edema , Exanthema , Eye Manifestations , Fever , Flavivirus , Hemorrhage , Korea , Myalgia , Sri Lanka , VolunteersABSTRACT
No abstract available.
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Humans , Glaucoma, Angle-Closure , Pseudoxanthoma ElasticumABSTRACT
No abstract available.
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Retinal Detachment , Retinal Perforations , RetinaldehydeABSTRACT
PURPOSE: To report a case of visual deterioration and atrophied retina after pars plana vitrectomy (PPV) and silicone oil tamponade for the treatment of retinal detachment with previous encircling scleral buckling. CASE SUMMARY: A 29-year-old female visited for treatment of rhegmatogenous retinal detachment (RRD) in the right eye which was not completely resolved after encircling scleral buckling. Logarithm of minimal angle of resolution (log MAR) and best corrected visual acuity (BCVA) was 0.3. Retinal detachment from 3 to 8 O'clock without macular involvement was identified. Pars plana vitrectomy, endophotocoagulation and silicone oil tamponade were performed. During the operation, retinal dialysis and retinal break at the superonasal periphery were observed. The patient complained of central scotoma at 2 days postoperatively and hyper-reflection of the inner retina was identified on optical coherence tomography (OCT). At 2 weeks postoperatively, the OCT image revealed a thin retina and impending macular hole. After 2 months, the silicone oil was removed. Although the retina was well attached, the retina remained atrophied and the log MAR BCVA was 0.16. CONCLUSIONS: We report a rare case with deteriorated visual acuity after PPV and silicone oil tamponade for the retreatment of RRD in an atopic dermatitis patient.
Subject(s)
Adult , Female , Humans , Dermatitis, Atopic , Dialysis , Reoperation , Retina , Retinal Detachment , Retinal Perforations , Retinaldehyde , Retreatment , Scleral Buckling , Scotoma , Silicon , Silicone Oils , Silicones , Tomography, Optical Coherence , Visual Acuity , VitrectomyABSTRACT
PURPOSE: To evaluate the relation between ocular biometry and anthropometric parameters in Korean adults with cataracts METHODS: The preoperative medical data of 150 eyes (150 patients) who underwent cataract surgery from November 2015 to March 2016. Anthropometric parameters include height, weight and body mass index (BMI). Ocular biometry includes axial length, anterior chamber depth, corneal curvature, lens thickness and central corneal thickness. The relation between ocular biometry and anthropometric parameters was evaluated using linear regression analysis. RESULTS: The mean age was 67.44 ± 10.83 years. The mean height, weight and BMI were 157.24 ± 9.16 cm, 60.50 ± 10.18 kg and 24.47 ± 3.59 kg/m2. The mean axial length, anterior chamber depth, corneal curvature, lens thickness and central corneal thickness were 23.51 ± 0.80 mm, 3.23 ± 0.42 mm, 44.49 ± 1.33 diopter, 4.44 ± 0.42 mm and 534.64 ± 31.90 µm. The height showed a significant positive relationship with axial length and anterior chamber depth and a significant negative relationship with average corneal curvature. However, there was no significant relationship with the central corneal thickness or lens thickness. The weight showed significant positive relationship with axial length. BMI was not related to any anthropometric parameters. Age showed a significant positive relationship with average corneal curvature and lens thickness and a negative relationship with height and anterior chamber depth. CONCLUSIONS: As height increases, the axial length and the anterior chamber depth increase and the corneal curvature become flatter. As age increases, the anterior chamber depth becomes shallower, the corneal curvature becomes steeper and the lens thickness increases.